On Thursday, the Reds earned a 3-0 win over their hosts at the Fooladshahr Stadium.
Mehdi Torabi gave the visiting team the lead from the penalty spot in the 16th minute.
Ali Alipour made it 2-0 in the 58th minute and Torabi was on target once again in the 65th minute.
Esteghlal sit atop the table with 25 points.
Sepahan are second with 24 points and one game in hand.
Shahr Khodro and Persepolis are third and fourth with 23 and 22 points, respectively.